Increased Sarcolipin Expression and Adrenergic Drive in Humans with Preserved Left Ventricular Ejection Fraction and Chronic Isolated Mitral Regurgitation Zheng et al: Sarcolipin and Adrenergic Signaling Pathways in Human MR
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چکیده
MD v ve Card rd d dio io io io iova va va va vasc sc sc sc scul ul ul u ular ar ar ar ar C C C Cen en en en ente t t t t r r r r r Abstract Background—There is currently no therapy proven to attenuate left ventricular (LV) dilatation
منابع مشابه
Increased sarcolipin expression and adrenergic drive in humans with preserved left ventricular ejection fraction and chronic isolated mitral regurgitation.
BACKGROUND There is currently no therapy proven to attenuate left ventricular (LV) dilatation and dysfunction in volume overload induced by isolated mitral regurgitation (MR). To better understand molecular signatures underlying isolated MR, we performed LV gene expression analyses and overlaid regulated genes into ingenuity pathway analysis in patients with isolated MR. METHODS AND RESULTS G...
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Background: Cardiac resynchronization therapy (CRT) has proved as an efficient treatment in patients with end stage Heart failure. Previous studies showed the beneficial long term effects of CRT on the severity of mitral regurgitation (MR). The aim of this study was to evaluate acute effects of CRT on severity of MR. Methods: This study was a double blind randomized trial performed from 1387 t...
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Certain subsets of high-risk mitral valve patients are not suitable candidates for transcatheter therapies. The objective of this report is to present a young patient with combined mitral valve and coronary artery disease to illustrate these challenges.In this report, we present a 47-year-old man with longstanding HIV infection who was referred with severe mitral regurgitation (MR) and profound...
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BACKGROUND It is generally accepted that the adrenergic nervous system provides inotropic support for the failing heart. However, the magnitude of this support has never been studied extensively. The present study was performed to test the hypothesis that the adrenergic nervous system is capable of maintaining indexes of pump and contractile function in the normal range despite significant inna...
متن کاملSecondary mitral regurgitation in heart failure with reduced or preserved left ventricular ejection fraction.
Secondary mitral regurgitation (MR) has been extensively studied in heart failure due to reduced ejection fraction. In contrast, the occurrence and the pathogenesis of secondary MR are much less known in heart failure with preserved ejection fraction (HFpEF). The present review aimed at describing this common but ignored feature of HFpEF.
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